As a DHT derivative, oxymetholone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites .  However, uniquely among DHT derivatives, oxymetholone is nonetheless associated with relatively high estrogenicity, and is known to have the potential to produce estrogenic side effects such as gynecomastia (rarely) and water retention .     It has been suggested that this may be due to direct binding to and activation of the estrogen receptor by oxymetholone. 
Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder. 
The truth is simple; there is no steroid like Trenbolone and while it may carry some potential adverse effects many men will supplement with no problem at all. You will find no steroid to pack such a punch on its own; in-fact, there are very few combinations and stacks that can be as potent as the Trenbolone hormone is on its own. For bulking and cutting this steroid has no equal and when combined with testosterone as it should be, if for no other reason than your health it is a hormone that cannot be beat safely making Trenbolonethe greatest anabolic androgenic steroid of all time.