Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote decines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit.
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For a common person with an overdose of paracetamol it is best to visit the doctor and seek immediate advice. If you are someone you know has had an overdose of paracetamol then whether to not symptoms start to surface you should visit the doctor. Earlier the better. Best within one hour of intake of it. And starts getting really dangerous after 24 hours of having taken he overdose. No self medication, no taking cues from people who have experienced this horror before or checking out the net for immediate assistance. Keep it simple. VISIT THE DOCTOR.