NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
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The homeopathically inclined dog owner may ask whether there is a natural prednisone substitute for dogs. It is thought that a number of fruits, vegetables, and natural oils may reproduce the anti-inflammatory effects of prednisone. However, the amount or combination needed to achieve the effects would likely be disruptive to a dog’s normal diet or produce ill effects on a dog’s digestion. If a dog’s condition is serious enough to require steroids such as prednisone or prednisolone, dietary supplements are probably going to prove insufficient.