Non-steroidal anti-inflammatory drug

The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.

Formulations of topical diclofenac, ibuprofen, ketoprofen, piroxicam, and indomethacin demonstrated significantly higher rates of clinical success (more participants with at least 50% pain relief) than matching topical placebo (moderate or high quality data ). Benzydamine did not. Three drug and formulation combinations had NNTs for clinical success below 4. For diclofenac, the Emulgel® formulation had the lowest NNT of (95% CI to ) in two studies using at least 50% pain intensity reduction as the outcome . Diclofenac plasters other than Flector® also had a low NNT of ( to ) based on good or excellent responses in some studies. Ketoprofen gel had an NNT of ( to ), from five studies in the 1980s, some with less well defined outcomes. Ibuprofen gel had an NNT of ( to ) from two studies with outcomes of marked improvement or complete remission. All other drug and formulation combinations had NNT values above 4, indicating lesser efficacy .

When and how much to take
NSAIDs should ideally be taken with some food, or at least with milk or yoghurt to avoid irritation of the gastric mucosa (. the inner lining of the stomach). It is important not to exceed the recommended dose to avoid possible serious side-effects. There is also no benefit in taking more than a certain dose, since these drugs have a ceiling effect. This means that above a certain dose, taking even more of this medication will not yield any extra beneficial effects, but will considerably increase the risk for side-effects.

Hi Norman, You might be interested in the following:
1) Turmeric extract – See more information and studies in my article “ Turmeric Extract is Effective as Ibuprofen for Knee Osteoarthritis “.
2) Gelatin – see more information and research in my article “ Gelatin and Osteoarthritis of the Knees “.
3) Sesame seeds – more information in my article “ How To Use Sesame Seeds For Knee Osteoarthritis “.
4) Tart cherries – see “ How to Fight Joint Pain and Inflammation With Tart Cherries “.
5) Anti-Inflammatory Smoothie for Joint Pain .
6) For pain relief – massaging the area with these 20 essential oils to relieve pain and inflammation , and/or consuming this anti-inflammatory and pain relieving turmeric ginger tea .
7) See more possible natural treatments HERE , and HERE .

Non-steroidal anti-inflammatory drug

non-steroidal anti-inflammatory drug

Hi Norman, You might be interested in the following:
1) Turmeric extract – See more information and studies in my article “ Turmeric Extract is Effective as Ibuprofen for Knee Osteoarthritis “.
2) Gelatin – see more information and research in my article “ Gelatin and Osteoarthritis of the Knees “.
3) Sesame seeds – more information in my article “ How To Use Sesame Seeds For Knee Osteoarthritis “.
4) Tart cherries – see “ How to Fight Joint Pain and Inflammation With Tart Cherries “.
5) Anti-Inflammatory Smoothie for Joint Pain .
6) For pain relief – massaging the area with these 20 essential oils to relieve pain and inflammation , and/or consuming this anti-inflammatory and pain relieving turmeric ginger tea .
7) See more possible natural treatments HERE , and HERE .

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