Infrastructure Grants are designed to support the development of tools, techniques and services of need to the neuromuscular research community. The main review criterion for this grant is need for the infrastructure to further research for the purpose of therapy development. Recipients of an MDA Infrastructure Grant must develop a plan to make this MDA-funded resource available to the research community and have a plan for sustaining the infrastructure beyond the period of MDA support. Letters of support from the community are an essential part of the application.
Skeletal problems associated with weak muscles in SMA include tight joints with limited range of movement, hip dislocations, spinal deformity, osteopenia, an increase risk of fractures and pain.  Weak muscles that normally stabilize joints such as the vertebral column lead to development of kyphosis and/or scoliosis and joint contracture.  Spine fusion is sometimes performed in people with SMA I/II once they reach the age of 8-10 to relieve the pressure of a deformed spine on the lungs. Furthermore, immobile individuals, posture and position on mobility devices as well as range of motion exercises, and bone strengthening can be important to prevent complications.  People with SMA might also benefit greatly from various forms of physiotherapy , occupational therapy and physical therapy.