Long acting beta agonist and steroid

The original drug in this class, Byetta (exenatide, given as two injections a day), was derived from a compound found in the saliva of the Gila monster, a lizard that lives in the southwestern US. This Gila spit compound has a structure similar to GLP-1 but is broken down more slowly by the enzyme DPP-4. Byetta received FDA approval in 2005. A second unrelated GLP-1 agonist Victoza (liraglutide, given as one injection a day) became available in 2010. Bydureon (exenatide extended-release, given as one injection a week after being mixed) received approval in 2012, and was followed by approval for a Bydureon pen (one injection a week, easier to mix) that should become available in the second half of 2014. Additional GLP-1 agonists are being developed.

These receptors, like those in the heart, are coupled to a Gs-protein , which stimulates the formation of cAMP . Although increased cAMP enhances cardiac myocyte contraction (see above), in vascular smooth muscle an increase in cAMP leads to smooth muscle relaxation. The reason for this is that cAMP inhibits myosin light chain kinase that is responsible for phosphorylating smooth muscle myosin. Therefore, increases in intracellular cAMP caused by β 2 -agonists inhibits myosin light chain kinase thereby producing less contractile force (., promoting relaxation).

SOURCES:
American Academy of Asthma, Allergy & Immunology: "Asthma" and "Allergy and Asthma Drug Guide."
National Jewish Medical and Research Center: "Inhaled Medication with a Metered Dose Inhaler (MDI)." 
Asthma Society of Canada: "How to Use Your Inhaler."
Science Daily: "New Asthma Inhaler Propellant Effective, but Costlier."
Children's Hospital Boston: "Allergy Treatment."
Boehringer Ingelheim: "US FDA Expands Approval of Tiotropium Respimat® for Maintenance Treatment of Asthma in Children."
FDA. Prescribing Information: Spiriva Respimat.

Therefore it becomes important for the Asthma patients to look for alternative therapies to support the body and breathing as well as remove toxins from the body and thereby aid in Asthma control. More importantly, the body metabolism and respiration has got to be strengthened and improved for better functioning off the body. The holistic treatment calls for maintain good personal hygiene as well as cleanliness around the house, in ensuring sufficient vitamins and nutrition are consumed and regular detoxification is carried out to improve the overall body health and vitality. Besides breathing exercises are a must on daily basis to ensure that the breathing capacity of the lungs is improved, the chest and respiratory passage muscles are strengthened and relaxed. The focus should also be to improve body immunity through healthy diet and removal of toxins.

Long acting beta agonist and steroid

long acting beta agonist and steroid

Therefore it becomes important for the Asthma patients to look for alternative therapies to support the body and breathing as well as remove toxins from the body and thereby aid in Asthma control. More importantly, the body metabolism and respiration has got to be strengthened and improved for better functioning off the body. The holistic treatment calls for maintain good personal hygiene as well as cleanliness around the house, in ensuring sufficient vitamins and nutrition are consumed and regular detoxification is carried out to improve the overall body health and vitality. Besides breathing exercises are a must on daily basis to ensure that the breathing capacity of the lungs is improved, the chest and respiratory passage muscles are strengthened and relaxed. The focus should also be to improve body immunity through healthy diet and removal of toxins.

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