Corticosteroid inhaler for asthma

QNASL Nasal Aerosol is a pressurized, nonaqueous solution in a metered-dose aerosol device intended ONLY for intranasal use. It contains a solution of beclomethasone dipropionate in propellant HFA-134a (1,1,1,2-tetrafluoroethane) and dehydrated ethanol. QNASL 40 mcg Nasal Aerosol delivers 40 mcg of beclomethasone dipropionate from the nasal actuator and 50 mcg from the valve. QNASL 80 mcg Nasal Aerosol delivers 80 mcg of beclomethasone dipropionate from the nasal actuator and 100 mcg from the valve. Each strength delivers 59 mg of solution from the valve with each actuation. Each canister of QNASL 40 mcg or 80 mcg Nasal Aerosol, contains  g of drug and excipients and each provides 120 actuations after priming. Additionally, QNASL 40 mcg Nasal Aerosol contains g of drug and excipients and provides 60 actuations after priming.

1. Remove blue cover.
2. Hold the base firmly and turn the mouthpiece in the direction of the arrow.
3. A recess (shaped to match the capsule) will now be visible in the base. Place capsule into the recess.
4. Return mouthpiece to original position.
5. Keep inhaler upright and firmly squeeze the two blue buttons once to puncture the capsule. Release buttons.
6. Breathe out to the side, away from the Aerolizer.
7. Place mouthpiece between the teeth and close lips firmly around it. Tilt head slightly back.
8. Breathe in deeply and steadily.
9. Remove Aerolizer from mouth and hold the breath for as long as possible—at least 10 seconds.
10. Breathe out slowly.
11. To take a second dose, open the inhaler, remove the empty capsule and repeat steps 3-8.
12. Replace cover on Aerolizer.

Use of QVAR with a spacer device in children less than 5 years of age is not recommended. In vitro dose characterization studies were performed with QVAR 40 mcg/actuation with the OptiChamber and AeroChamber Plus ® spacer utilizing inspiratory flows representative of children under 5 years old. These studies indicated that the amount of medication delivered through the spacing device decreased rapidly with increasing wait times of 5 to 10 seconds as shown in Table 2. If QVAR is used with a spacer device, it is important to inhale immediately.

There is no clinical syndrome associated with an overdosage of cromolyn sodium . In several animal species acute toxicity with cromolyn sodium occurs only with very high exposure levels. No deaths occurred at the highest oral doses tested in mice, 8,000 mg/kg (approximately 5,100 and 2,700 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m 2 basis) or in rats, 8,000 mg/kg (approximately 10,000 and 5,400 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m 2 basis).

Corticosteroid inhaler for asthma

corticosteroid inhaler for asthma

There is no clinical syndrome associated with an overdosage of cromolyn sodium . In several animal species acute toxicity with cromolyn sodium occurs only with very high exposure levels. No deaths occurred at the highest oral doses tested in mice, 8,000 mg/kg (approximately 5,100 and 2,700 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m 2 basis) or in rats, 8,000 mg/kg (approximately 10,000 and 5,400 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m 2 basis).

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